Sepsis is a life-threatening organ dysfunction caused by the body's immune system overreacting in response to an infection. ... there are several stand out symptoms that usually indicate possible. CARE PLANNING CPG IP Sepsis NBNI Setting: Inpatient Population: Newborn, NICU www.elsevierclinicalsolutions.com Version: 1.1 Status: Last Updated: 11/11/2019 Page 8 of 9.